Licking County Humane Society Executive Director Lori Carlson says the animals were stacked "bottom to top" in the van when it was discovered in the parking lot of a hotel in Hebron, east of Columbus, on Saturday afternoon.
Carlson said the dogs, some just a few weeks old, had coats covered with feces and urine.
The driver reported being hired by the breeder to take the 50 adult dogs and 12 puppies to an animal rescue in New Jersey. They now are in Ohio animal shelters.
The county prosecutor's office will consider charges in the case.