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Smoke rises from a fire burning in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco's Mission Bay neighborhood sent an enormous plume of black smoke high into the sky. There were no initial reports of injuries. The four-alarm fire that began about 5 p.m. was ravaging a high-rise building under construction and moving down a block. Fire-suppression systems had not yet been installed in the building, making the battle against the blaze more difficult, Fire Department spokeswoman Mindy Talmadge said.
SAN FRANCISCO—San Francisco firefighters have prevented a major blaze from spreading from a condominium construction site to nearby buildings.

The five-alarm fire started burning at around 5 p.m. on Tuesday in the city's Mission Bay neighborhood, a onetime industrial area that lies along the San Francisco Bay.

The fire sent an enormous plume of black smoke high into the sky and eventually caused a wall of the structure to collapse. Officials say fire-suppression systems had not yet been installed in the building, making the battle against the blaze more difficult.

Fire Chief Joanne Hayes-White tells the San Francisco Chronicle ( http://bit.ly/1cSlq6y) that the fire is the city's largest in several years.

Smoke rises from a fire in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco’s Mission Bay neighborhood sent an
Smoke rises from a fire in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco's Mission Bay neighborhood sent an enormous plume of black smoke high into the sky. There were no initial reports of injuries. The four-alarm fire that began about 5 p.m. was ravaging a high-rise building under construction and moving down a block. Fire-suppression systems had not yet been installed in the building, making the battle against the blaze more difficult, Fire Department spokeswoman Mindy Talmadge said. ((AP Photo/Jeff Chiu))

Mission Bay is home to a University of California, San Francisco medical campus and is close to AT&T Park, the San Francisco Giants stadium.

A firefighter sprays water from a hose onto a fire in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco’s Mission Bay
A firefighter sprays water from a hose onto a fire in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco's Mission Bay neighborhood sent an enormous plume of black smoke high into the sky. There were no initial reports of injuries. The four-alarm fire that began about 5 p.m. was ravaging a high-rise building under construction and moving down a block. Fire-suppression systems had not yet been installed in the building, making the battle against the blaze more difficult, Fire Department spokeswoman Mindy Talmadge said. ((AP Photo/Jeff Chiu))

A firefighter sprays water onto a fire in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco’s Mission Bay neighborhood
A firefighter sprays water onto a fire in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco's Mission Bay neighborhood sent an enormous plume of black smoke high into the sky. There were no initial reports of injuries. The four-alarm fire that began about 5 p.m. was ravaging a high-rise building under construction and moving down a block. Fire-suppression systems had not yet been installed in the building, making the battle against the blaze more difficult, Fire Department spokeswoman Mindy Talmadge said. ((AP Photo/Jeff Chiu))

Smoke rises from a fire burning in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco’s Mission Bay neighborhood sent an
Smoke rises from a fire burning in San Francisco, Tuesday, March 11, 2014. The major fire burning in San Francisco's Mission Bay neighborhood sent an enormous plume of black smoke high into the sky. There were no initial reports of injuries. The four-alarm fire that began about 5 p.m. was ravaging a high-rise building under construction and moving down a block. Fire-suppression systems had not yet been installed in the building, making the battle against the blaze more difficult, Fire Department spokeswoman Mindy Talmadge said. ((AP Photo/Jeff Chiu))