Chris Davenport had 17 points with six rebounds for the Ospreys (8-7). Jalen Nesbitt came off the bench to score 15 and Travis Wallace added 14 points and a team-high 11 rebounds.
The Ospreys mounted a 13-4 run in the game's first five minutes to lead 43-29 at the break. Nesbitt's 3-pointer at 9:20 in the second period extended the North Florida lead to 20, 66-46. From there, the Ospreys—who led by double digits throughout most of the game—never had to look back.
Ike Nwamu came off the bench to lead the Bears (10-5) with 20 points. Darious Moten had 16 points and seven rebounds.
The loss snapped a Mercer five-game winning streak.