CLEMSON, S.C. (AP) Jameis Winston threw for 444 yards and three touchdowns and No. 5 Florida State crushed No. 3 Clemson 51-14 Saturday night, making statement that should be heard from Alabama to Oregon.

The Atlantic Coast Conference's game of the year, billed as maybe the league's biggest game ever, quickly became a Seminoles' seminar on how to take apart a top-five opponent on its hostile home turf.

Winston was 22 for 34 for Florida State (6-0, 4-0 ACC). His first throw was a 22-yard touchdown to Kelvin Benjamin, and he scrambled for a 4-yard touchdown that made it 41-7 with 4:04 left in the third quarter.

Tajh Boyd threw two interceptions for Clemson, and his first-quarter fumble was returned 37 yards for a touchdown by Mario Edwards. Clemson (6-1, 4-1) turned it over a season-high four times, including on the first play from scrimmage.