Rollins drove a 2-2 pitch from Dan Jennings (0-1) into the seats in left. It was the 201st career homer for Rollins, but just the second game ender of his career. The first came June 23, 2010, against Cleveland.
B.J. Rosenberg (1-0) pitched a scoreless 10th for the victory.
Rollins finished with three hits and hot-hitting Chase Utley had two doubles and drove in a run for Philadelphia, which has won 12 of 15 against the Marlins.