After a poor start to the season, Domenicali says "it's time to make an important change. As head, I take on the responsibility of the situation we are in."
Domenicali replaced Jean Todt in 2008 and helped Ferrari win the constructors' championship in his first year in charge. However, the team has failed to secure a driver's title under his guidance.
Ferrari has not won since Fernando Alonso's victory at the Spanish Grand Prix almost a year ago, the team's worst run in nearly 20 years.